Neonatal and pediatric pharmacology therapeutic principles in practice pdf
A quarter century of progress in paediatric clinical pharmacology: A personal viewCommentators have focused primarily on the expected contributions of clinical pharmacology as a core discipline in adult internal medicine and its subspecialties, but the even greater potential importance in paediatrics has generally been ignored. The term quickly became popular but has, in some ways, contributed to continuing uncertainty about the central mission of paediatric clinical pharmacology. Not all observers are clear as to whether the orphans are children themselves, inadequately studied therapies, or even the diseases that have been deprived of treatment with fully evaluated and appropriately labelled medications. Despite obstacles, the discipline of paediatric clinical pharmacology has evolved over the past quarter century in parallel to, but frequently lagging behind, the course of adult clinical pharmacology. Paediatric clinical pharmacologists are increasingly confronted by the need to expand the relevant basic knowledge of pharmacology and toxicology in order to enable a move beyond treatment with small molecule chemical entities to comfort with a broader therapeutic armamentarium that includes more complex biological products. Furthermore, rare, genetically determined conditions commonly presenting in childhood have usually been treated empirically leaving such patients without the benefit of targeted and fully evaluated treatments
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Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Test Drive. Request more information. Description Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents.