Metabolic engineering principles and methodologies pdf free download
Metabolic Engineering: Principles and Methodologies - PDF Free DownloadMetabolic engineering is the practice of optimizing genetic and regulatory processes within cells to increase the cells' production of a certain substance. Metabolic engineering specifically seeks to mathematically model these networks, calculate a yield of useful products, and pin point parts of the network that constrain the production of these products. Once again this modified network can be modeled to calculate the new product yield. The ultimate goal of metabolic engineering is to be able to use these organisms to produce valuable substances on an industrial scale in a cost effective manner. Current examples include producing beer , wine , cheese , pharmaceuticals , and other biotechnology products.
Metabolic engineering and industrial products
Plant Secondary Metabolism Engineering
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Metabolic Engineering Principles and Methodologies
Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes. The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes. Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems. Microbial physiologists, chemical engineers, biochemists, and biotechnologists who work on the application of molecular techniques to the alteration of cell cultures and microorganisms.